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α2巨球蛋白样蛋白1抗体 α2ML1
产品名称 | 英文名称 | 货号 |
α2巨球蛋白样蛋白1抗体 α2ML1 | A2ML1 | GOY-01K1267 |
商品属性：
英文名称: A2ML1
中文名:α2巨球蛋白样蛋白1抗体 α2ML1
别 名；A2ML 1; Alpha 2
macroglobulin like 1; Alpha 2 macroglobulin like protein 1; C3 and PZP like
alpha 2 macroglobulin domain containing protein 9; CPAMD9; DKFZp686C1729;
DKFZp686D2011; DKFZp686G1812; DKFZp686L1821; DKFZp686O1010; FLJ16045; FLJ25179;
FLJ39129; FLJ41597; FLJ41598; FLJ41607; A2ML1_HUMAN. α2ML1
研究领域；细胞生物 免疫学 神经生物学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Horse, )
产品应用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；159kDa
细胞定位；细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human A2ML1: 31-130/1454
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
alpha-2-Macroglobulin (alpha-2M) is a
homotetrameric serum protein consisting of four identical subunits that form
dimers through disulfide bonds. Initially, alpha-2M was characterized as a
pan-proteinase inhibitor that was able to “bait” proteinases into cleaving specific
peptide sequences on alpha-2M. This interaction induces a conformational
change in alpha-2M, thus enabling it to “trap” the proteinase and further inhibit its activity. Subsequently,
alpha-2M has been shown to function as a carrier protein and regulator of
cytokines during inflammation. Circulating transforming growth factor beta
(TGF beta) in serum is primarily bound to alpha-2M, which renders TGF∫ inactive. Mutations and deletions in the gene encoding alpha-2M
are associated with an increased incidence of Alzheimer's Disease (AD).
Alpha-2-macroglobulin-like protein 1 (alpha2ML1) is a related protein that is
expressed in the epidermis and may play a role in keratinocyte
differentiation. A2ML1 is a new member of the alpha 2-macroglobulin
protease inhibitor family, and shares most the characteristics of this
family. It is the first family member detected in the epidermis and may play
an important role during desquamation by inhibiting extracellular proteases.
The alpha-macroglobulin (AM) superfamily of proteins contains both complement
components and protease inhibitors, including A2M and A2ML1. AM proteins
display a unique trap mechanism of inhibition, by which the AM inhibitor
undergoes a major conformational change upon its cleavage by a protease, thus
trapping the protease and blocking it from subsequent substrate binding. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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