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ABI1/SSH3BP1蛋白抗体
产品名称 | 英文名称 | 货号 |
ABI1/SSH3BP1蛋白抗体 | ABI1 | GOY-01K1548 |
商品属性：
英文名称: ABI1
中文名:ABI1/SSH3BP1蛋白抗体
别 名；Abelson
interactor 1; Abelson interactor 1; ABI 1; ABI-1 Abl binding protein 4; Abl
interactor 1; Abl interactor protein 1 long; AblBP4; Ablphilin 1; E3B1; Eps8
binding protein; Eps8 SH3 domain binding protein; Hssh3bp1; NAP1; NAP1BP;
Spectrin SH3 domain binding protein 1; SSH3BP; SSH3BP1; ABI1_HUMAN.
研究领域；免疫学 信号转导 转录调节因子
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, )
产品应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；55kDa
细胞定位；细胞核 细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human ABI1: 101-200/508
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
May act in negative regulation of cell growth and
transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or
ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming
activity of Abelson murine leukemia virus(v-Abl) after overexpression in
fibroblasts. May play a role in regulation EGF-induced Erk pathway
activation. Involved in cytoskeletal reorganization and EGFR signaling.
Together with EPS8 participates in transduction of signals from Ras to Rac.
In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific
guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an
adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA
(By similarity). Recruits WASF1 to lamellipodia and there seems to regulate
WASF1 protein level. Function: May act in negative regulation of cell growth and
transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or
ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming
activity of Abelson murine leukemia virus(v-Abl) after overexpression in
fibroblasts. May play a role in regulation EGF-induced Erk pathway
activation. Involved in cytoskeletal reorganization and EGFR signaling.
Together with EPS8 participates in transduction of signals from Ras to Rac.
In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific
guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an
adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA
(By similarity). Recruits WASF1 to lamellipodia and there seems to regulate
WASF1 protein level. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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