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Fyn结合蛋白抗体
产品名称 | 英文名称 | 货号 |
Fyn结合蛋白抗体 | ADAP/FYB | GOY-01K1718 |
商品属性：
英文名称: ADAP/FYB
中文名:Fyn结合蛋白抗体
别 名；ADAP; Adhesion
and degranulation promoting adaptor protein; FYB 120/130; Fyb; FYB-120/130;
FYB_HUMAN; FYN binding protein; FYN T binding protein; FYN-binding protein;
FYN-T-binding protein; p120/p130; PRO0823; SLAP 130; SLAP-130; SLAP130; SLP 76
associated phosphoprotein; SLP-76-associated phosphoprotein; SLP76 associated
phosphoprotein.
研究领域；细胞生物 信号转导 结合蛋白 细胞类型标志物
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
产品应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；85kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human FYB/ADAP: 501-600/783
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
Fyb (Fyn binding protein) and the anchoring
proteins SKAP55 (src kinase-associated phosphoprotein) and SKAP55-R
(SKAP55-related protein) associate with the tyrosine kinase p59fyn (1–3). SKAP55 and SKAP55-R bind to Fyb through their SH3
domains and function as substrates for p59Fyn in resting T cells (1–3). SKAP55 contains an amino-terminal pleckstrin homology domain
and a carboxy-terminal SH3 domain binding motif of adjacent arginine and
lysine residues followed by tandem tyrosines (i.e. RKxxYxxY) (4,5). SKAP55-R,
similar in overall structure to SKAP55, contains a coiled-coil N-terminal
domain (1,2). SKAP55 associates with SLAP-130, another component of the Fyn
complex, which plays a role in the regulation of signaling events initiated
by lymphocyte antigen receptors leading up to T cell activation (6). The
human Fyb gene maps to chromosome 5p13.1 and encodes a 783 amino acid protein
(7). Function: Acts as an adapter protein of the FYN and LCP2
signaling cascades in T cells. Modulates the expression of interleukin-2
(IL-2). Involved in platelet activation. Prevents the degradation of SKAP1
and SKAP2. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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