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Acinus抗体

简要描述:Acinus抗体免 疫 原;KLH conjugated synthetic peptide derived from human Acinus: 501-600/1341

  • 产品型号:GOY-01K1870
  • 厂商性质:科研
  • 更新时间:2023-10-24 00:00:00
  • 访  问  量:426

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Acinus抗体


产品名称

英文名称

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Acinus抗体

Acinus

GOY-01K1870

商品属性:

英文名称: Acinus

中文名:Acinus抗体

    名;ACIN 1; ACIN1; ACINU_HUMAN; Acinus; ACN; Apoptotic chromatin condensation inducer 1; Apoptotic chromatin condensation inducer in the nucleus; DKFZp667N107; fSAP152; functional spliceosome-associated protein 152; KIAA0670.

研究领域;细胞生物  神经生物学  信号转导  细胞凋亡

抗体来源;Rabbit

克隆类型;Polyclonal

交叉反应;(predicted: Human, Mouse, Rat, Dog, Cow, Horse, )

产品应用;ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量;148kDa

细胞定位;细胞核

    状;Liquid

    度;1mg/ml

免 疫 原;KLH conjugated synthetic peptide derived from human Acinus: 501-600/1341

    型;IgG

纯化方法;affinity purified by Protein A

缓 冲 液;0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件;Shipped at 4. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

注意事项;This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍:

Chromatin condensation and nuclear fragmentation  (CCNF) are the hallmarks of apoptosis. CCNF is triggered by the activation of  members of the caspase family, caspase activated DNase (CAD/DFF40), and  several novel proteins including AIF and CIDE. A new inducer of chromatin  condensation was recently identified and designated Acinus (for apoptotic  chromatin condensation inducer in the nucleus). Acinus is cleaved by Caspase  3 and an additional unknown protease generating a small active peptide p17,  which causes chromatin condensation in vitro when it is added to purified  nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus  is ubiquitously expressed. Three different spliced forms of Acinus have been  identified in human and mouse and designated Acinus L (1341 amino acids),  Acinus S (583 amino acids) and Acinus S' (614 amino acids)

Function:

Component of a splicing-dependent multiprotein  exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is  a dynamic structure consisting of a few core proteins and several more  peripheral nuclear and cytoplasmic associated factors that join the complex  only transiently either during EJC assembly or during subsequent mRNA  metabolism. Induces apoptotic chromatin condensation after activation by  CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.

 

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多克隆抗体制备:

我公司合成抗原,保证阳性血清和抗体ELISA效价达到1:32000,由蛋白抗原制备的多抗,保证WB检测结果是阳性。技术服务实行分步报价,按节点收费,为客户节约成本。

鼠单克隆抗体制备:

客户可根据项目实际需求情况灵活选择进行,我公司将为您的项目提供专业的建议。在制备过程中,与客户互动验证,确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时,也能满足客户抗体最终应用验证需求。技术服务实行分步报价,按节点收费,为客户节约成本。

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重组抗体表达服务:

重组抗体技术使制备人源化抗体和人源抗体成为可能,而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台,能为客户提供各种类型的重组抗体表达服务,包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达,抗体人源化改造及表达等服务。

单项免疫学及检测服务:

我公司也为客户提供单项免疫学和检测服务,如动物免疫、动物饲养、抗体修饰服务(如FITC,HRP等的标记)、以及ELISA,WB,IHC,DB等检测服务。

抗体定制服务:

已注册商标,主要用于抗体药物发现和开发,是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务,主要面向工业客户。

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