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NOC2家族样蛋白抗体
产品名称 | 英文名称 | 货号 |
NOC2家族样蛋白抗体 | NOC2L | GOY-01K1784 |
商品属性：
英文名称: NOC2L
中文名:NOC2家族样蛋白抗体
别 名；NIR; NOC2 like;
Novel INHAT (inhibitor of histone acetyltransferase) repressor; Nucleolar
complex associated 2 homolog (S. cerevisiae); Protein NOC2 homolog;
NOC2L_HUMAN.
研究领域；细胞生物 信号转导 细胞凋亡 转录调节因子 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Pig, Cow, Sheep, )
产品应用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；85kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human NOC2L: 251-350/749
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
NOC2L is a transcriptional corepressor with
inhibitor of histone acetyltransferase (INHAT) activity. NOC2L or NIR (Novel
INHAT Repressor) is ubiquitously expressed throughout embryonic development
and adulthood. It is a potent transcriptional corepressor that is not blocked
by histone deacetylase inhibitors and is capable of silencing both basal and
activator-driven transcription. NOC2L directly binds to nucleosomes and core
histones and prevents acetylation by histone acetyltransferases, thus acting
as a bona fide INHAT. Acts as an inhibitor of histone acetyltransferase
activity; prevents acetylation of all core histones by the EP300/p300 histone
acetyltransferase at p53/TP53-regulated target promoters in a histone
deacetylases (HDAC)-independent manner. Acts as a transcription corepressor
of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter.
Involved in the regulation of p53/TP53-dependent apoptosis. Associates
together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. Subunit: Interacts with p53/TP53. Interacts (via the N- and
C-terminus domains) with AURKB (via the middle kinase domain). Interacts with
TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3
(via N-terminus and non-acetylated form preferentially). Associates with core
histones and nucleosomes. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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