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SEMCAP3蛋白抗体
产品名称 | 英文名称 | 货号 |
SEMCAP3蛋白抗体 | SEMCAP3 | GOY-01K2219 |
商品属性：
英文名称: SEMCAP3
中文名:SEMCAP3蛋白抗体
别 名；Ligand of Numb
protein X 3; likely ortholog of mouse semaF cytoplasmic domain associated
protein 3; LNX3; PDZ domain containing ring finger 3; Protein SEMACAP3;
SEMACAP3; Semaphorin cytoplasmic domain associated protein; PZRN3_HUMAN.
研究领域；细胞生物 发育生物学 细胞周期蛋白 细胞分化
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, )
产品应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；120kDa
细胞定位；细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human SEMCAP3/LNX3: 951-1066/1066
亚 型；IgG
纯化方法；affinity purified
by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
PDZRN3 contains a RING-finger motif in its
N-terminal region, two PDZ domains in its central region and a
consensus-binding motif for PDZ domains at its C-terminus. It was identified
in silico as a homolog of the protein known as LNX1 or SEMCAP1, which
possesses ubiquitin ligase activity and binds the membrane protein Semaphorin
4C. However, PDZRN3 itself has not previously been characterized. We have now
evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown
to be expressed in various human tissues including the heart, skeletal muscle
and liver and its expression in mouse skeletal muscle was developmentally
regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into
myotubes and injury-induced muscle regeneration in vivo were found to be
accompanied by up-regulation of PDZRN3. The differentiation-associated
increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin
and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA
interference inhibited the formation of myotubes as well as the associated
up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that
PDZRN3 plays an essential role in the differentiation of myoblasts into
myotubes by acting either downstream or independently of myogenin. E3 ubiquitin-protein ligase. Plays an important
role in regulating the surface level of MUSK on myotubes. Mediates the
ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation.
Might contribute to terminal myogenic differentiation (By similarity). |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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