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转绿激活蛋白SRCAP抗体
产品名称 | 英文名称 | 货号 |
转绿激活蛋白SRCAP抗体 | SRCAP | GOY-01K0617 |
商品属性：
英文名称: SRCAP
中文名:转绿激活蛋白SRCAP抗体
别 名；DOMO1; EAF1;
Helicase SRCAP; Snf2 related CBP activator protein; SWR1; SRCAP_HUMAN.
研究领域；细胞生物 神经生物学 信号转导 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
产品应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；343kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human SRCAP: 665-780/3230
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
SRCAP (Snf2-related CREBBP activator protein),
also known as EAF1, SWR1, or DOMO1, is a 3,230 amino acid protein that
belongs to a family of helicases and contains one HSA domain, one helicase
C-terminal domain, one helicase ATP-binding domain and three A.T hook
DNA-binding domains. Localized to the nucleus, SRCAP functions as a catalytic
component of the SRCAP complex, a multi-protein structure that mediates the
ATP-dependent exchange of histone dimers for nucleosomal histones, an event
that regulates the transcription of select genes via chromatin remodeling.
Additionally, the SRCAP complex acts as a coactivator for steroid
receptor-mediated transcription, Notch-mediated transcription and
CREB-mediated transcription. SRCAP is expressed as multiple alternatively
spliced isoforms and is subject to DNA damage-dependent phosphorylation by
ATM or ATR. Function: Catalytic component of the SRCAP complex which
mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for
nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes
by chromatin remodeling. Acts as a coactivator for CREB-mediated
transcription, steroid receptor-mediated transcription, and Notch-mediated
transcription (from SwissProt). |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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