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T-激肽抗体
产品名称 | 英文名称 | 货号 |
T-激肽抗体 | T-kinin | GOY-01K5610 |
商品属性：
英文名称: T-kinin
中文名:T-激肽抗体
别 名；HMW Kininogen
Heavy Chain; HMW Kininogen; Kininogen-1 heavy chain; BDK; Kininogen 1;
Kininogen1; Kininogen-1; KNG1; Alpha-2-thiol proteinase inhibitor; Fitzgerald
factor; High molecular weight kininogen; HMWK; HMWK heavy chain;
Ile-Ser-Bradykinin; Kallidin I; Kallidin II; Kininogen 1; Kininogen 1 heavy
chain; KNG; KNG1_HUMAN; Williams-Fitzgerald-Flaujeac factor.
研究领域；细胞生物 信号转导 生长因子和激素 激酶和磷酸酶 细胞骨架 细胞外基质
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Rabbit, )
产品应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理论分子量；2kDa
细胞定位；细胞外基质 分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human T-kinin: 376-389/644
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
This gene uses alternative splicing to generate
two different proteins- high molecular weight kininogen (HMWK) and low
molecular weight kininogen (LMWK). HMWK is essential for blood coagulation
and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide
causing numerous physiological effects, is released from HMWK. In contrast to
HMWK, LMWK is not involved in blood coagulation. Three transcript variants
encoding different isoforms have been found for this gene.[provided by
RefSeq, Oct 2009]. Kininogens are inhibitors of thiol proteases; (2)
HMW-kininogen plays an important role in blood coagulation by helping to
position optimally prekallikrein and factor XI next to factor XII; (3)
HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of
thrombocytes; (4) the active peptide bradykinin that is released from
HMW-kininogen shows a variety of physiological effects: (4A) influence in
smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis
and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of
inflammation and causes (4E1) increase in vascular permeability, (4E2)
stimulation of nociceptors (4E3) release of other mediators of inflammation
(e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via
bradykinin action, indirectly via endothelium-derived relaxing factor
action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6)
LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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