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GBT1蛋白抗体
产品名称 | 英文名称 | 货号 |
GBT1蛋白抗体 | Transducin alpha | GOY-01K2538 |
商品属性：
英文名称: Transducin alpha
中文名:GBT1蛋白抗体
别 名；CSNBAD3; GBT1;
GNAT1; GNATR; GNAT1_HUMAN； guanine nucleotide binding
protein (G protein) alpha transducing activity polypeptide 1; guanine
nucleotide binding protein G(T) alpha 1 subunit; guanine nucleotide-binding
protein G(t) subunit alpha-1; Rod specific transducin; rod-type transducin
alpha subunit; transducin alpha-1 chain; transducin, rod-specific.
研究领域；细胞生物 神经生物学 信号转导 G蛋白信号
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
产品应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；40kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Transducin alpha: 11-110/350
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
Transducin is a 3-subunit guanine nucleotide-binding
protein (G protein) which stimulates the coupling of rhodopsin and
cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits
in rods and cones are encoded by separate genes. This gene encodes the alpha
subunit in rods. This gene is also expressed in other cells, and has been
implicated in bitter taste transduction in rat taste cells. Mutations in this
gene result in autosomal dominant congenital stationary night blindness.
Multiple alternatively spliced variants, encoding the same protein, have been
identified. [provided by RefSeq, Feb 2009] Function: Vision involves the conversion of light into
electrochemical signals that are processed by the retina and subsequently
sent to and interpreted by the brain. The process of converting light into an
electrochemical signal begins when the membrane-bound protein, rhodopsin,
absorbs light within the retina. Photoexcitation of rhodopsin causes the
cytoplasmic surface of the protein to become catalytically active. In the
active state, rhodopsin activates transducin, a GTP binding protein. Once
activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase
(PDE). The decrease of intracellular cGMP concentration causes the ion
channels within the outer segment of the rod or cone to close, thus causing
membrane hyperpolarization and, eventually, signal transmission. Rhodopsin
activity is believed to be shut off by phosphorylation followed by binding of
the soluble protein, arrestin. Transducin, once activated by rhodopsin, promotes
the hydrolysis of cGMP by PDE. The subunit composition of transducin differs
between different photoreceptor cells. Rod transducin consists of rod
transducin alpha (Tr alpha), T beta, and T gamma. Cone transducin is composed
of cone transducin alpha (Tc alpha), T beta and T gamma. Differential
transducin subunit composition of transducin is believed to be responsible
for the different light sensitivities between photoreceptive cells. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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