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泛素蛋白连接酶E3α2抗体
产品名称 | 英文名称 | 货号 |
泛素蛋白连接酶E3α2抗体 | UBR2 | GOY-01K1905 |
商品属性：
英文名称: UBR2
中文名:泛素蛋白连接酶E3α2抗体
别 名；E3 ubiquitin
protein ligase UBR2; N recognin 2; Ubiquitin ligase E3 alpha II; Ubiquitin
protein ligase E3 alpha 2; Ubiquitin protein ligase E3 component n recognin 2;
UBR 2; UBR2_HUMAN; N-recognin-2; Ubiquitin-protein ligase E3-alpha-2;
Ubiquitin-protein ligase E3-alpha-II.
研究领域；细胞生物 免疫学 发育生物学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
产品应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；44kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human UBR2: 801-900/1755
亚 型；IgG
纯化方法；affinity purified
by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
Ubiquitination is an important mechanism through
which three classes of enzymes act in concert to target short-lived or
abnormal proteins for destruction. The three classes of enzymes involved in
ubiquitination are the ubiquitin-activating enzymes (E1s), the
ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s).
Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a
1755 amino acid protein that contains one UBR-type zinc finger and one
RING-type zinc finger. Participating in protein modification events within
the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that
recognizes and binds proteins that contain destabilizing N-terminal residues,
thereby leading to their ubiquitination and subsequent degradation. Mice
lacking Ubr2 are infertile due to defects in male meiosis. E3 ubiquitin-protein ligase which is a component
of the N-end rule pathway. Recognizes and binds to proteins bearing specific
N-terminal residues that are destabilizing according to the N-end rule,
leading to their ubiquitination and subsequent degradation. Plays a critical
role in chromatin inactivation and chromosome-wide transcriptional silencing
during meiosis via ubiquitination of histone H2A. Binds leucine and is a
negative regulator of the leucine-mTOR signaling pathway, thereby controlling
cell growth. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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