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UL16结合蛋白1蛋白抗体
产品名称 | 英文名称 | 货号 |
UL16结合蛋白1蛋白抗体 | ULBP1 | GOY-01K5963 |
商品属性：
英文名称: ULBP1
中文名:UL16结合蛋白1蛋白抗体
别 名；ALCAN-beta;
N2DL-1; N2DL1; NKG2D ligand 1 precursor; NKG2DL1; RAET1I; Retinoic acid early transcript
1I; UL16; UL16 binding protein 1; UL16-binding protein 1; N2DL1_HUMAN.
研究领域；细胞生物 免疫学 自然杀伤细胞
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；Rat, (predicted: Human, )
产品应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；25kDa
细胞定位；细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human ULBP1: 121-220/244
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
N2DL1 is a human rat mouse ligand for the NKG2D
receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple
signaling pathways in primary NK cells, resulting in the production of
cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization
and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal
transduction pathway. The interaction with UL16 blocks the interaction with
the NKG2D receptor, providing a mechanism by which CMV infected cells might
escape the immune system. UL16 also causes ULBP1 to be retained in the ER and
cis-Golgi apparatus so that it does not reach the cell surface. ULBP1 is
expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range
of tissues. Ligand for the NKG2D receptor, together with at
least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary
NK cells, resulting in the production of cytokines and chemokines. Binding of
ULBPs ligands to NKG2D induces calcium mobilization and activation of the
JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV
infected cells, interacts with soluble CMV glycoprotein UL16. The interaction
with UL16 blocked the interaction with the NKG2D receptor, providing a
mechanism by which CMV infected cells might escape the immune system. UL16
also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it
does not reach the cell surface. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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