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凋亡相关蛋白激酶3抗体
产品名称 | 英文名称 | 货号 |
凋亡相关蛋白激酶3抗体 | ZIP Kinase | GOY-01K2050 |
商品属性：
英文名称: ZIP Kinase
中文名:凋亡相关蛋白激酶3抗体
别 名；DAPK3; Death
associated protein kinase 3; DAP kinase 3; DAP like kinase; Dapk 3; Dapk3;
Death associated kinase 3; Death associated protein kinase 3; Dlk; EC 2.7.11.1;
FLJ36473; ZIP; ZIP kinase; ZIPK; DAPK3_HUMAN.
研究领域；染色质和核信号 信号转导 转录调节因子
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
产品应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理论分子量；52kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human DAPK3: 30-130/454
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
Apoptosis is mediated by death domain containing
adapter molecules and a caspase family of proteases. Certainserine/threonine
protein kinases, such as ASK1 and RIP, are mediators of apoptosis. A novel
serine/threonine kinase that mediates apoptosis was recently identified and
designated ZIP kinase. ZIP kinase contains an N terminal kinase domain and a
C terminal leucine zipper structure and binds to ATF4 that is a member of
ATF/CREBfamily. ZIP kinase has high sequence homology to DAP kinase (death
associated protein kinase), which is a mediator of apoptosis induced by gamma
interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP
kinases represent a novel kinase family, which mediates apoptosis through
their catalytic activities. The messenger RNA was ubiquitously expressed in
various tissues. Serine/threonine kinase which is involved in the
regulation of apoptosis, autophagy, transcription, translation, actin
cytoskeleton reorganization, cell motility, smooth muscle contraction, and
mitosis, particularly cytokinesis. Regulates both type I apoptotic and type
II autophagic cell deaths signal, depending on the cellular setting. The
former is caspase-dependent, while the latter is caspase-independent and is
characterized by the accumulation of autophagic vesicles. Regulates myosin
phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle,
regulates myosin either directly by phosphorylating MYL12B and MYL9 or
through inhibition of smooth muscle myosin phosphatase (SMPP1M) via
phosphorylation of PPP1R12A, and the inhibition of SMPP1M functions to enhance
muscle responsiveness to Ca(2+) and promote a contractile state. Enhances
transcription from AR-responsive promoters in a hormone- and kinase-dependent
manner. Phosphorylates STAT3 and enhances its transcriptional activity.
Positively regulates the canonical Wnt/beta-catenin signaling through
interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby
influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3
on 'Thr-11' at centromeres during mitosis. Involved in the formation of
promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear
domains in the eukaryotic cell nucleus, and which is involved in oncogenesis
and viral infection. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma
activation which is causing RPL13A release from the ribosome, its association
with the GAIT complex and its subsequent involvement in transcript-selective
translation inhibition. Isoform 2 can phosphorylate myosin, PPP1R12A and
MYL12B |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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