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乙酰基赖氨酸/乙酰化赖氨酸抗体
产品名称 | 英文名称 | 货号 |
乙酰基赖氨酸/乙酰化赖氨酸抗体 | Acetylated Lysine | GOY-01K1361 |
商品属性：
英文名称: Acetylated Lysine
中文名:乙酰基赖氨酸/乙酰化赖氨酸抗体
别 名；Ac-lysine; Ac
lysine; Ac-K; Ac K; Ac-Lys; Ac Lys; acetyl-Lysine; acetyl Lysine; acetyl-Lys;
acetyl Lys. 赖乙酰化；
产品类型小分子抗体 乙酰化抗体
研究领域；细胞生物 免疫学 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
产品应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated acetyl Lysine
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产品介绍:
In the nucleus, DNA is tightly packed into
nucleosomes generating an environment which is highly repressive towards DNA
processes such as transcription. Acetylation of lysine residues within
proteins has emerged as an important mechanism used by cells to overcome this
repression. The acetylation of non-histone proteins such as transcription
factors, as well as histones appears to be involved in this process.
Acetylation may result in structural transitions as well as specific
signaling within discrete chromatin domains. The role of acetylation in
intracellular signaling has been inferred from the binding of acetylated
peptides by the conserved bromodomain. Furthermore, recent findings suggest
that bromodomain/acetylated-lysine recognition can serve as a regulatory
mechanism in protein-protein interactions in numerous cellular processes such
as chromatin remodeling and transcriptional activation. The reversible lysine
acetylation of histones and non-histone proteins plays a vital role in the
regulation of many cellular processes including chromatin dynamics and transcription,
gene silencing, cell cycle progression, apoptosis, differentiation, DNA
replication, DNA repair, nuclear import, and neuronal repression. More than
20 acetyltransferases and 18 deacetylases have been identified so far, but
the mechanistic details of substrate selection and site specificity of these
enzymes remain unclear. Over 40 transcription factors and 30 other nuclear,
cytoplasmic, bacterial, and viral proteins have been shown to be acetylated
in vivo. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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