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ATP依赖解旋酶SMARCA2抗体

简要描述：ATP依赖解旋酶SMARCA2抗体免疫原；KLH conjugated synthetic peptide derived from human SMARCA2/BRM: 1401-1590/1590

产品型号：GOY-01K2668
厂商性质：科研
更新时间：2023-10-24 00:00:00
访问量：34

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ATP依赖解旋酶SMARCA2抗体

产品名称	英文名称	货号
ATP依赖解旋酶SMARCA2抗体	SMARCA2	GOY-01K2668

商品属性：

英文名称: SMARCA2

中文名:ATP依赖解旋酶SMARCA2抗体

别名；BRM; ATP dependent helicase SMARCA2; Global transcription activator homologous sequence; BRG1-associated factor 190B; BAF190B; hBRM; hSNF2a; Possible global transcription activator SNF2L2 (EC:3.6.4.-); SMARCA2; SMCA2_HUMAN; SNF2 alpha; SNF2 like 2; SNF2/SWI2 like protein 2; SNF2A; SNF2LA; SNF2L2; Sth1p; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 2.

研究领域；细胞生物免疫学表观遗传学

抗体来源；Rabbit

克隆类型；Polyclonal

交叉反应；Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, )

产品应用；ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量；230kDa

细胞定位；细胞核

性状；Liquid

浓度；1mg/ml

免疫原；KLH conjugated synthetic peptide derived from human SMARCA2/BRM: 1401-1590/1590

亚型；IgG

纯化方法；affinity purified by Protein A

缓冲液；0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件；Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

注意事项；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍:

A transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. SMARCA2 / BRM belongs to the SNF2/RAD54 helicase family, is a homologue of the Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma proteins. It contains a methyl lysine containing bromo domain and an HSA domain. The yeast protein SNF2, also known as SWI2, is involved in transcriptional activation of numerous genes. It contains a domain that is highly conserved among several known helicases and is required for transcriptional activity. SNF2/SWI2 is highly homologous to the Drosophila protein 'brahma' (brm). Although the 2 proteins show nuclear localization during interphase, they are excluded from the condensed chromosomes during mitosis. They found that the level of BRM, but not BRG1, was strongly reduced during mitosis. Phosphorylation of hbrm and BRG1 did not disrupt their association with SNF5 but correlated with a decreased affinity for the nuclear structure in early M phase.

Function:

Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

多克隆抗体制备：

我公司合成抗原，保证阳性血清和抗体ELISA效价达到1：32000，由蛋白抗原制备的多抗，保证WB检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。

鼠单克隆抗体制备:

客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体ELISA阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。

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重组抗体表达服务:

重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。

单项免疫学及检测服务:

我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如FITC，HRP等的标记）、以及ELISA，WB，IHC，DB等检测服务。

抗体定制服务:

已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。

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