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脑多巴胺神经营养因子抗体免 疫 原；KLH conjugated synthetic peptide derived from human ARMETL1: 101-187/187
维甲酸调节核基质相关蛋白抗体注意事项；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Tissue specificity: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell. Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
芳香烃受体核转录蛋白2抗体免 疫 原；KLH conjugated synthetic peptide derived from human ARNT2: 351-450/717
尾侧型同源转录因子1抗体注意事项；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: Could play a role in the terminal differentiation of the intestine.
肌动蛋白相关蛋白2/3亚型4抗体免 疫 原；KLH conjugated synthetic peptide derived from human ARPC4/p20-ARC: 1-100/168
尾型同源盒转录因子4抗体注意事项；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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